Abstract:Objective: To investigate the effect of carbazochrome sodium sulfonate for injection combined with tranexamic acid on perioperative blood loss in patients with femoral neck fracture. Methods：A total of 120 patients with femoral neck fracture undergoing surgical treatment were randomly divided into control group and observation group, with 60 cases in each group. Five minutes before skin incision, both groups were given intravenous infusion of tranexamic acid 1 g. Immediately after the operation, the observation group was given intravenous infusion of carbazochrome sodium sulfonate for injection, while the control group was given intravenous infusion of normal saline. The perioperative blood loss of the two groups was recorded. The levels of fibrinogen degradation product (FDP) and D-dimer in peripheral blood of the patients were detected before and 1 day after operation, and the levels of serum interleukin-6 (IL-6) and C-reactive protein (CRP) were detected. The postoperative hospitalization time and complications of the two groups were recorded. Results： Compared with the control group, the total blood loss and hidden blood loss in the observation group were decreased (P<0.05), and the postoperative drainage volume, maximum Hb decrease value and allogeneic blood transfusion were significantly decreased (P<0.05). One day after operation, the levels of FDP, D-dimer, IL-6 and CRP in the two groups increased (P<0.05), but compared with the control group, the levels of FDP, D-dimer, IL-6 and CRP in the observation group were lower(P<0.05). Compared with the control group, the postoperative hospital stay in the observation group was shorter(P<0.05). There was no significant difference in the incidence of infection and lower extremity intermuscular venous thrombosis between the two groups (P>0.05). Conclusion：The use of carbazochrome sodium sulfonate for injection combined with tranexamic acid can reduce perioperative blood loss, inhibit fibrinolysis, reduce inflammation, shorten postoperative hospital stay, and do not increase complications in patients with femoral neck fracture.

Key words:femoral neck fracture,perioperative blood loss,tranexamic acid,carbazochrome sodium sulfonate for injection,inflammation