Alzheimer’s disease is still a difficult problem in medical field since its discovery. This article reviews the relationship between blood-brain barrier （BBB） and Alzheimer’s disease. A large number of studies have identified elevated BBB leakage in Alzheimer’s disease patients，and ApoE4 is the strongest genetic risk factor for late onset Alzheimer’s disease. This paper focuses on the causes of BBB damage and how to repair BBB to achieve the therapeutic effect of Alzheimer’s disease.