Curcumin (Cur) is a diketone compound extracted from the rhizomes of the genus turmeric, which has a wide range of pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, and neuroprotection, but has low solubility, short half-life, low bioavailability, difficult to penetrate the blood-brain barrier and other shortcomings limit its clinical application. In recent years, it has been prepared into liposomes, solid dispersions, polymer nanoparticles, polymer micelles, nanosuspensions, etc., which significantly improved the solubility, bioavailability and targeting of Cur, and improved drug activity. This article reviewed the nano-preparations of Cur, aiming to provide references for its further research and development.