Objective：To investigate the pharmacological effects of 5-HT2A/D2 receptor balancing antagonist NH809 on schizophrenia in vivo. Methods：The effects of NH809 on schizophrenia in vivo were evaluated by MK-801 hydrogen maleat（0.3 mg·kg ^-1，ip） induced hyperactivity model in mice，apomorphine （1 mg·kg ^-1，sc） induced climbing model in mice and conditioned avoidance response（CAR） in rats，and compared with risperidone. Results：NH809 had dose-dependent inhibitory effect on MK-801 hydrogen maleate induced high activity model，apomorphine-induced climbing behavior in mice and conditioned avoidance response in vivo，with ED50 of 0.04，0.05 and 0.24 mg·kg ^-1，respectively. The ED50 of risperidone in these three models were 0.06，0.68 and 0.60 mg·kg ^-1，respectively. Conclusion：NH809 has significant pharmacological effects on several animal models of schizophrenia，and its activity in vivo is better than risperidone.