The occurrence and development of gastric cancer is a multi-step and multi factor complex process，which mainly involves DNA mutation，changes of genetic factors and abnormal changes of various cell signal transduction. Phosphatidylinositol 3-protein kinase （PI3K）/protein kinase B （AKT） signaling pathway is involved in the malignant process of tumor cells. The disorder of this pathway can cause a variety of diseases. In recent years，due to the in-depth study of tumor molecular basis，it is found that the activation of this pathway is closely related to the proliferation，invasion，metastasis，apoptosis and angiogenesis of gastric cancer cells. At present，targeting this signal pathway has become a new trend in antitumor research. The research progress of gastric cancer and PI3K/AKT signal pathway is summarized as follows.