Abstract:

Alzheimer’s disease(AD)is a common neurodegenerative disease in old age and has been published by world health organization(WHO)as one of the largest global public health issues facing mankind. The main clinical symptom is the progressive decline of learning and memory ability. The neuropathological changes of AD include senile plaque(SP)formed byβ-amyloid protein(Aβ)of accumulated outside of neuon，neurofibrillary tangle(NFT)formed by hyperphosphorylated Tau protein of inside the neuron，neuron loss and degeneration，synapse decrease and so on. Especially，the abnormal neurogenesis is also involved in the neuropathological process of AD. There are many studies have showed that neurogenesis is a process of neural stem cells in hippocampal dentate gyrus of adult mammals to produce new neuron. The increased adult neurogenesis can compensate the injured neurons and save the learning and memory impairment. Then，the promotion of adult hippocampal neurogenesis may be beneficial to treatment of AD. The present paper summarizes the relationship between the adult hippocampal neurogenesis and Alzheimer’s disease.

Key words:neurogenesis,Alzheimer’s disease,review