Objective: To investigate the clinical characteristics of patients with Huntington's disease patients, especially the atypical clinical symptoms, to deepen the understanding of the clinical characteristics of Huntington's disease. Methods: The clinical data of one HD patient admitted to the Department of Neurology of the First Hospital Affiliated to Hebei North College in January 2022 were collected under the principle of patient's informed and voluntary consent, and the relevant literature was reviewed and followed up. Results: Two members of this patient's family had already developed symptoms of involuntary limb movements, and this pre-documented person had early comorbid dysarthria with a CAG copy number of 43, and it was understood from the relevant literature review that speech alterations are an early symptom of HD, which may precede the onset of other motor and cognitive symptoms. Conclusion: The vast majority of HD has a positive family history and is clinically characterised by slowly progressive chorea, psychotic disorders and dementia, with speech alterations in the early stages and dysarthria and dysphagia in the later stages.