Objective：To investigate the therapeutic effect of sulpiride tablets combined with lurasidone tablets on schizophrenia. Methods: 80 patients with schizophrenia were randomly divided into control group (n=40) and observation group (n=40), they were treated with sulpiride tablets and sulpiride tablets combined with lurasidone tablets respectively. Both groups were treated for 8 weeks. The therapeutic effects of the two groups were evaluated. The changes of mental symptoms, cognitive function [Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)], social function [Personal and Social Performance Scale (PSP)] and serum prolactin (PRL) levels before and after treatment were compared between the two groups, and the adverse reactions were counted. Results: Comparing with the control group (75.00%), the total effective rate of treatment in the observation group (95.00%) was higher(P<0.05). After treatment, the mental symptom score of the observation group was lower, and the RBANS score and PSP score were significantly higher comparing with the control group(P<0.05). After treatment, the serum PRL of the two groups increased significantly(P<0.05), and the difference between the two groups shows no significant (P>0.05). Compared with the control group, there was no significant increase in the incidence of adverse reactions in the observation group (P>0.05). Conclusion: On the basis of sulpiride tablets, the combination of lurasidone tablets in patients with schizophrenia can improve the efficacy and cognitive function of patients, and has no significant effect on serum PRL, with good safety.