Objective: The food and medicine industry is an integral part of the national strategy to develop a “healthy China”. Resveratrol is a naturally occurring compound that has been shown to be biologically active in various diseases such as inflammation, heart disease and cancer. The aim of this study was to investigate the analgesic effects of resveratrol in acute and chronic pain in mice. Methods: In this study, the analgesic effects of resveratrol were evaluated by constructing mouse models of acute pain (acetic acid-induced torsion, formalin-induced persistent pain) and chronic pain (paclitaxel-induced neuropathic pain). Results: The behavioural results showed that resveratrol was effective in reducing acute and chronic pain behaviour in mice and exhibited beneficial effects. Conclusion: Therefore, resveratrol may be a potential drug for the treatment of acute and chronic pain in mice. This study provides a certain theoretical basis for subsequent related studies and offers new ideas and methods for safe and effective clinical analgesia.