Objective： To investigate the efficacy of Feixiankang Granules combined with Tetrandrine Tablets in the treatment of pneumoconiosis and its effect on lung function and serum IL-8 and IFN-γ levels. Methods: From June 2021 to May 2023,72 patients with pneumoconiosis admitted to the outpatient or inpatient department of the occupational disease department of Hengyang Hospital of Traditional Chinese Medicine were selected as the research objects. According to the random number table method, the patients were randomly divided into control group(n=36) and observation group (n=36). Both groups were given conventional symptomatic treatment. The control group was treated with tetrandrine tablets on this basis, and the observation group was treated with Feixiankang granules on the basis of the control group. After 3 months of treatment, the clinical efficacy, TCM symptom scores, lung function [maximum ventilation volume (MVV) and forced expiratory volume in one second (FEV1)], serum IL-8, IFN-γ levels and adverse reactions during treatment were compared between the two groups. Results: The total effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the scores of main symptoms, secondary symptoms and total scores of TCM symptoms in the two groups decreased(P<0.05), and those in the observation group were lower(P<0.05). After treatment, MVV and FEV1 in both groups increased (P<0.05), and those in the observation group were higher(P<0.05). IL-8 decreased in both groups(P<0.05), and the observation group was lower(P<0.05). IFN-γ in both groups increased(P<0.05), and the observation group was higher(P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion: Feixiankang granule combined with tetrandrine tablets can significantly improve the curative effect, improve lung function, reduce serum IL-8 level and increase IFN-γ level in patients with pneumoconiosis.