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Abstract

Abstract:Present article reviewed the pharmacological progress on anti-aging and anti- Alzheimer’s disease of Ganoderma（Lingzhi）. G.lucidum polysaccharide significantly enhanced the immunity in aged mice，which involved that increasing plaque forming cells，promoting T and B lymphocyte proliferation reaction and mixed lymphocyte reaction，and enhancing interleukin-2 production in aged mice. The immune-enhancing effect of G.lucidum polysaccharides may relate to increase DNA polymeraseαactivity of spleen cells in aged mice. G.lucidum polysaccharide can delay the aging of cells，organs and tissues by anti-oxidative stress. G. lucidum polysaccharides，triterpenes and spores can improve of learning and memory function and histopathological injury of the hippocampus in animal model of Alzheimer disease，and its mechanism is closely related to antioxidative and scavenging free radicals effect by Ganoderma（Lingzhi）

Key words:Ganoderma lucidum,polysaccharides,triterpenes,aging,immunity,Alzheimer&,rsquo,s disease

CLC Number:

R964

LIN Zhi-bin.Pharmacological Progress of Ganoderma on Anti-aging and Anti-Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2018, 8(1): 9-15.

References

1. Xia Dong, Lin Zhi-bin, Li Rong-zhi, et al. Effects of Ganoderma Polysaccharides on immune function in mice[J]. J Beijing Med Univ, 1989, 21: 533-537.

2. 雷林生, 林志彬. 灵芝多糖对老年小鼠脾细胞DNA多聚酶α活性及免疫功能的影响[J]. 药学学报, 1993, 28(8): 577-582.

3. Li Wen-juan, Nie Shao-ping, Peng Xiao-ping, et al. Ganoderma atrum polysaccharide improves age-related oxidative stress and immune impairment in mice[J]. J Agric Food Chem, 2012, 60(6):1413-8.

4. 雷林生, 林志彬. 灵芝多糖对老年小鼠脾细胞DNA多聚酶α活性及免疫功能的影响[J]. 药学学报, 1993, 28: 577-582 与2重复

5. 林志彬. 灵芝抗氧化清除自由基作用的研究[J]. 菌物研究, 2014, 12(2):63-70.

6. Li Xiang, Liang Jie. Ganoderma lucidum polysaccharide prevents oxidation and skin aging[J]. Chinese J Tissue Engineering Research, 2013, 17( 41):7272-7276.

7. 谢韶琼, 廖万清. 探讨灵芝多糖对H2O2 诱导的角质形成细胞氧化应激性损伤的保护作用[J]. 中国皮肤性病学杂志, 2006, 20(2):77-78.

8. 余强, 聂少平, 李文娟. 黑灵芝多糖对D-半乳糖致衰老小鼠的作用研究[J]. 食品科学, 2009, 30(17):305-307.

9. 魏晓东, 邓连瑞, 张惠丹, 等. 灵芝多糖抗H2 O2 诱导的HDF细胞衰老及其机制的研究[J].中国老年学杂志, 2009, 29(11):1347-1349.

10. Wang Ming-Fu, Chan Yin-Ching, Wu Ching-Lein, et al. Effects of Ganoderma on aging and learning and memory ability in senescence accelerated mice[J]. International Congress Series, 2004, 1260: 399– 404.

11. 郭燕君, 袁华, 甘胜伟, 等. 灵芝多糖对Aβ25-35 诱导阿尔茨海默病模型大鼠脑组织的保护作用[J]. 中国组织化学与细胞化学杂志, 2006, 15: 447-451.

12. 郭燕君, 袁华, 张俐娜, 等. 灵芝多糖对阿尔茨海默病大鼠海马组织形态学及抗氧化能力的影响[J]. 解剖学报, 2006, 37(5): 509-513.

13. 郭燕君, 李平, 袁华. 灵芝多糖对阿尔茨海默病大鼠学习记忆影响及海马细胞凋亡的关系[J]. 解剖学杂志, 2008, 31(3):376-378.

14. 晏涛，陈世保，徐蕾，等. 灵芝多糖对阿尔茨海默病大鼠学习记忆和氧化应激的影响[J].陕西医学杂志, 2011, 40(4)：387-425.

15. 张骐，阎志勇，贾学江，等.灵芝多糖肽对氧化应激损伤PC12细胞的保护作用与神经生长因子的比较[J]. 中国临床康复, 2005, 9(32):138-140.

16. 张跃平, 袁华, 黎莉, 等. 灵芝多糖对AD模型大鼠海马组织Caspase-3和FasL表达的影响[J].中国组织化学与细胞化学杂志, 2008, 17(5):484-489.

17. 杨红梅，王黎，陈洁，等. 灵芝多糖肽对Alzheimer样大鼠海马超微结构和抗氧化能力的影响[J]. 中国老年学杂志, 2009, 29(18): 2351-2353.

18. 袁电杰，张印发，姚春香. 灵芝多糖对阿尔茨海默病模型大鼠海马内突触及突触素表达的影响[J].中国实验方剂学杂志, 2011, 3：151-155.

19. 黄勇攀, 刘丙进, 喻南慧, 等. 灵芝三萜类化合物对AD模型大鼠脑组织保护作用的研究[J].贵阳医学院学报, 2008, 33(6):662-664.

20. 张玥，罗俊，黄能慧，等. 灵芝三萜类化合物对AD大鼠学习记忆能力和总抗氧化能力的影响[J]. 中华中医药杂志, 2012, 9：2318-2321.

21. 张玥，罗俊，黄能慧，等. 灵芝三萜类化合物对ＡＤ大鼠海马神经元凋亡的影响[J].贵阳医学院报, 2016, 41(5), doi: 10.19367/j.cnki.1000-2707.2016.05.009.

22. Zhou Yan, Qu Ze-qiang, Zeng Yuan-shan, et al. Neuroprotective effect of preadministration with Ganoderma lucidum spore on rathippocampus[J]. Experimental and Toxicologic Pathology, 2012, 64: 673–680.

23. 秦川，吴善球，陈保生, 等.灵芝制剂治疗APP/PS-1 阿尔茨海默病转基因小鼠模型的病理学改变[J]. 中国医学科学院学报, DOI: 10. 3881 /j. issn. 1000-503X. 2017. 04. 015.

24. Ravneet Kaur, Varinder Singh, Richa Shri. Anti-amnesic effects of Ganoderma species: A possible cholinergic and antioxidant mechanism[J]. Biomedicine & Pharmacotherapy，2017， 92：1055–1061.

25. 陶思祥，叶传书. 赤灵芝对老年人细胞免疫功能的影响[J].中华老年医学杂志, 1977, 57: 48.

26. 颜世东，闫社因，齐德芹，等. 芝精口服液治疗阿尔茨海默病93例疗效观察[J]. 广西中医药, 2007, 30(3):154-156.

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Pharmacological Progress of Ganoderma on Anti-aging and Anti-Alzheimer’s Disease

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