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Abstract

Abstract:Objective：To analyze the characteristics of the existing animal models and the accordance with the clinical symptoms based on the clinical symptoms of Chinese and Western medicine in depression.Methods：Through combing the related literatures at home and abroad in recent years，we compared and analyzed the characteristics of depression，clinical symptoms and the more modern depression model.Results：The detection of symptoms，most of the existing concept of animal models of depression observed the biochemical indicators and clinical symptoms，the main index of agreement is relatively high，a few animal models are consistent with clinical symptoms is relatively low.Conclusion：The animal models of depression should be improved according to the characteristics of clinical diseases，which will be closer to the characteristics of human diseases in the etiology，pathogenesis and disease characteristics，and provide more reliable experimental support for the clinical.

Key words:clinical characteristics of the disease,depression,animal model,anastomosis

CAO Li-hua，BAI Ming，FANG Xiao-yan，WANG Can，MIAO Ming-san.Analysis of Animal Models of Depression Based on Clinical Symptoms[J]. Acta Neuropharmacologica, 2016, 6(4): 19-23.

References

[1] 秦碧勇, 戴立磊, 汪键, 等. 抑郁症患者自杀风险与共病数量、抑郁程度的相关性研究[J]. 重庆医学, 2016, 45(13): 1810-1812.

[2]Kerri Smith. Mental health: a world of depression[J]. Nature, 2014, 515(7526): 181．

[3] 徐艳芩, 缪楹, 刘连忠, 等. 抑郁症患者家庭环境调查研究[J]. 华中科技大学学报: 医学版, 2017, 46(02): 224-226+240.

[4] Shae E Quirk, Lana J Williams, Adrienne O'Neill. The association between diet quality,dietary patterns and depression in adults: a systematic review[J]. BMC Psychiatry, 2013, 13: 175.

[5] 何海然, 薛占霞. 抑郁症相关发病机制的研究进展[J]. 神经药理学报, 2016, 6(02): 20-25.

[6] 董栋, 王蕊. 抑郁症相关受体、细胞因子及信号通路的研究进展[J]. 神经药理学报, 2012, 2(05): 24-30.

[7] 许二平, 苗明三, 尚立芝. 基于抑郁症细胞因子、神经-内分泌发病机制的中医药治疗新进展[J]. 河南中医, 2017, 37(02): 233-237.

[8] Yuriko Iuakura, Hiroyuki Nava, lchiro Sora, et al. Dopamine Dl receptor-induced signaling through Trk B receptors in striatal neurons[J]. J Biol Chem, 2008, 283(23): 15799-15806.

[9]Cory Sykora, Mitch Amor, Evelyn Schlenker. Age and hypothyroidism affect dopamine modulation of breathing and D2receptor levels[J]. Respir Physiol Neurobiol, 2013, 185(2): 257-264.

[10]邓朔, 张鸿燕. 抑郁症发病机制的神经免疫相关靶点研究现状[J]. 中国临床药理学杂志, 2017, 33(03): 280-283.

[11]程博琳, 方晓艳, 苗明三. 抑郁症的分子机制及中医药治疗抑郁症特点[J]. 中医学报, 2014, 29(02): 212-214

[12] David J Nutt. The Hamilton Depression Scale-accelerator or break on antidepressant drug discovery[J]. J Neurol Neurosurg Psychiatry, 2014, 85(2): 119-120.

[13] 中华医学会精神分会. 中囯精神疾病分类方案与诊断标准[J].济南: 山东科学技术出版社版, 2001, (3): 86-87.

[14] 陈小平. 抑郁症患者中医不同辨证分型脑内5-HT、NE、DA神经递质变化规律的研究[D].北京: 北京中医药大学, 2014.

[15] 中华中医药学会脑病专业委员会(国家中医药管理局全国脑病重点专科抑郁症协作组).抑郁症中医证候诊断标准及治疗方案[J]. 北京中医药大学学报, 2011, 34(12): 810-811.

[16] Henry A Nasrallah, Tracy Hopkins, Sarah K Pixley. Differential effects of antipsychotic and antidepressant drugs on neurogenic regions in rats[J]. Brain Res, 2010, 1354:23-29.

[17] 陈姣, 楚世峰, 王真真, 等. GSK3在抑郁症发病机制中的研究进展[J]. 神经药理学报, 2014, 4(05): 44-54.

[18] 王闪闪. 抑郁症患者发病进程中神经机制的探索[D].重庆: 西南大学, 2015.

[19] 姚莉红, 成翔, 张蕾, 等. 慢性应激性刺激对大鼠行为的影响-抑郁症模型的建立[J].南通大学学报: 医学版, 2013, 33(1): 35-37.

[20] 于亚青, 王林林, 王静静, 等. 柴胡疏肝散醇提物对抑郁模型小鼠的抗抑郁作用[J]. 神经药理学报, 2014, 4(05): 8-14.

[21] 袁翠, 高千惠, 刘雪林, 等.抑郁症的嗅觉功能缺陷:发现与观点[J]. 医学与哲学(B), 2016, 37(08): 60-63+67.

[22] 刘奇, 袁丽, 李德顺, 等. 百合知母汤对抑郁症大鼠行为及单胺递质的影响[J]. 中华中医药学刊, 2016, 34(07): 1729-1732.

[23] 孙秀萍, 张楠, 高杰, 等. 慢性束缚应激模型致焦虑和抑郁共病的行为学研究[J]. 中国比较医学杂志, 2015, 25(06): 18-22.

[24] 罕园园, 代解杰. 抑郁症动物模型与其发病机制研究的进展[J]. 中国实验动物学报, 2016, 24(03): 321-326.

[25] 杨婵娟, 安瑞娣, 杨俊卿, 等. 造模时间对慢性不可预见性刺激致大鼠抑郁模型的影响[J]. 四川动物, 2015, 24(03): 383-388.

[26] 薛涛, 邬丽莎, 刘新民, 等. 抑郁症动物模型及评价方法研究进展[J]. 中国实验动物学报, 2015, 23(03): 321-326.

[27] 黄巧玲, 吴华丽, 蔡旻煊, 等. 皮质酮与慢性不可预见性应激诱导的两种抑郁症模型比较[J]. 解剖学报, 2017, 48(03): 273-281.

[28] 高杉, 李苒.抑郁症动物模型及其评价标准研究进展[J]. 天津中医药大学学报, 2012, 31(1): 57-60.

[29] 曹利华, 苗明三. 基于围绝经期抑郁症临床病症特点的动物模型分析[J]. 中华中医药杂志, 2016, 31(05): 1643-1647.

Analysis of Animal Models of Depression Based on Clinical Symptoms

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