神经药理学报››2016,Vol. 6››Issue (2): 46-52.DOI:10.3969/j.issn.2095-1396.2016.02.008
王欢欢，薛茜，邹玉安
出版日期:2016-04-26发布日期:2016-05-10通讯作者:薛茜，女，教授，硕士，研究生导师；研究方向：神经内科临床方向；E-mail：xueqian6166@163.com 邹玉安，男，教授，硕士，研究生导师；研究方向：神经药理学；E-mail：zya8857111@sohu.com作者简介:王欢欢，女，硕士研究生；研究方向：缺血性脑血管病研究；E-mail：1271643589@qq.com基金资助:
河北省医学科学研究重点课题（No.20150054）
WANG Huan-huan，XUE Qian，ZOU Yu-an
Online:2016-04-26Published:2016-05-10Contact:薛茜，女，教授，硕士，研究生导师；研究方向：神经内科临床方向；E-mail：xueqian6166@163.com 邹玉安，男，教授，硕士，研究生导师；研究方向：神经药理学；E-mail：zya8857111@sohu.comAbout author:王欢欢，女，硕士研究生；研究方向：缺血性脑血管病研究；E-mail：1271643589@qq.comSupported by:
河北省医学科学研究重点课题（No.20150054）
摘要：脑缺血预处理是指给予脑组织一个低于阈值的缺血缺氧刺激，激活机体的内源性保护因子或信号通路，从而产生脑缺血耐受的现象。预处理涉及的神经保护机制包括抗凋亡、抗氧化应激、抑制炎症反应、调节兴奋性/ 抑制性神经递质、血管重塑、保护血脑屏障、维持能量代谢/ 线粒体膜电位以及激活DNA 修复和自我修复等作用。而氧化应激损伤、自由基连锁反应是缺血再灌注损伤的核心病理环节，该文对内源性抗氧化应激机制在缺血预处理引起的再灌注损伤中作用进行综述，为缺血缺氧性脑病的临床治疗提供理论依据。
中图分类号:
王欢欢, 薛茜, 邹玉安.内源性抗氧化应激机制在缺血预处理与缺血再灌注损伤中的研究进展[J]. 神经药理学报, 2016, 6(2): 46-52.
WANG Huan-huan, XUE Qian, ZOU Yu-an.Research Progress of the Mechanism of Endogenous Antioxidant Stress in Cerebral Ischemic Preconditioning and Ischemia Reperfusion Injury[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(2): 46-52.
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