Tripartite motif proteins (TRIM) are a class of proteins involved in a wide range of biological processes, including cell growth and differentiation, development, apoptosis, immune response, and tumorigenesis. Among them, TRIM32 is an E3 ubiquitin ligase that belongs to the TRIM protein family. Although there are few studies on TRIM32, its role in maintaining the physiological function of the nervous system is extremely important. Therefore, this review aims to review the role of TRIM32 in neurological diseases.