Kidney Disease is a serious threat to people's health, so it is very important to replicate the animal model which is more similar to human kidney disease in order to further explore the pathogenesis of Kidney Disease and find therapeutic drugs. In this paper, animal models of diabetic nephropathy, glomerulonephritis, hypertensive nephropathy, uric acid nephropathy, obstructive nephropathy, drug-induced renal injury and ischemic nephropathy were reviewed.