%A GUO Bao, LIU Zi-ming, JING Yong-shuai, ZHANG Dan-shen
%T Correlation Between Wnt Signaling Pathway and Alzheimer's Disease and Its Targets
%0 Journal Article
%D 2023
%J ACTA NEUROPHARMACOLOGICA
%R 10.3969/j.issn.2095-1396.2023.01.010
%P 56-
%V 13
%N 1
%U {http://actanp.hebeinu.edu.cn/CN/abstract/article_858.shtml}
%8 2023-02-26
%X <div style="text-align:justify;">
	Alzheimer's disease (AD) is a neurological disease
related to aging, its pathological characteristics are extracellular amyloid β
protein (Aβ) deposition, tau protein hyperphosphorylation and synaptic damage,
etc., the production of AD greatly affects people's lives and brings huge
economic burden to people. Wnt signaling pathway is an important signaling
pathway, plays a very important role in neurodegenerative disease Alzheimer's
disease, because Wnt signaling pathway is inhibited by a variety of pathogenic
mechanisms in the AD brain, so the activation of Wnt signal-related pathway is
of great help to the treatment of AD. At present, there are
also many traditional Chinese medicine monomers and synthetics that play a role
in the treatment and prevention of AD through the Wnt pathway, and this article
reviews the correlation, potential therapeutic targets and related effective
drugs of Wnt signaling pathway and the treatment of AD.
</div>