|星空彩票电脑版
%A DONG Xiao-hua, MENG Xian-yong, ZHANG Li, YANG Jian-ming %T
Effects of Osthole on Neuronal Apoptosis and Cell Cycle in AD Rats%0 Journal Article %D 2012 %J ACTA NEUROPHARMACOLOGICA %R %P 7-14 %V 2 %N 3 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_84.shtml} %8 2012-06-26 %X
Objective:To observe the influence of osthole on neuronal apoptosis and cell cycle in Alzheimer's disease (AD) rats and to study the neuroprotective effects and its mechanism.
Methods:An intracerebroventricular (i.c.v.) injection of β-amyloid peptide (Aβ
25-35) was administrated to establish AD rat model. Osthole(12.5，25.0 mg·kg
-1) was injected intraperitoneally to rats and cognitive functions, neuronal apoptosis and cell cycle of AD rats were observed.
Results:Osthole could improve spatial learning and memory abilities of AD rats, reduce neuronal apoptosis, increase the percentage of S phase cells, promote the G
2/M phase cells to divide further, strengthen the cell proliferation activity, regulate cell cycle and benefit to the maintenance of normal physiological function of neurons.
Conclusion:Osthole hasneuronal protection through reducing neuronal apoptosis and regulating cell cycle, which may be one of mechanism of improving learning and memory disorder in AD rats.