The Neuroprotective Effect of Ginsenoside Compound K on Neurodegenerative Diseases %0 Journal Article %D 2021 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2021.04.009 %P 49- %V 11 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_776.shtml} %8 2021-08-26 %X

In recent years，the incidence and mortality of neurodegenerative diseases have increased with the acceleration of population aging in China，such as Alzheimer’s disease，vascular dementia，Parkinson’s disease，ischemia cerebral vascular disease，epilepsy and so on. Ginseng is a traditional herb in China，which has the effects of anti-aging，calming the mind and promoting intelligence. Ginsenoside is the main active ingredient in ginseng. Ginsenoside compound K is the metabolite of protopanaxadiol ginsenoside in the intestine. It was found that CK has neuroprotective effects. The neuroprotective mechanism of CK was involved in antioxidant stress，anti-inflammation，increased energy metabolism，anti-autophagy，antiapoptosis，regulation of neurotransmitters and so on. Here we review the neuroprotective effect of CK on neurodegenerative diseases and the neuroprotective mechanism of CK，in order to provide theoretical reference for the treatment and research and development of drugs for neurodegenerative diseases.