Based on the National Patent Database to Study the Rules of Using Traditional Chinese Medicine Compound Prescriptions for the Treatment of Pulmonary Heart Disease %0 Journal Article %D 2021 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2021.04.003 %P 9- %V 11 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_770.shtml} %8 2021-08-26 %X
Objective：Based on data mining，to explore medication rules in the treatment of pulmonary heart disease by mining the traditional Chinese medicine compound prescriptions in the national patent database，in order to provide inference for clinical treatment of pulmonary heart disease. Methods：The related traditional Chinese medicine patent compounds in the national patent database were precisely extracted，and the patent compounds meeting the screening criteria entered into Excel 2021 to establish a database，which could be used to count the the nature，flavor and meridians of traditional Chinese medicine. IBM SPSS Modeler 18.0 and IBM SPSS Statistic 23.0 software were applied to conduct the association rule，cluster analysis and factor analysis of high-frequency traditional Chinese medicine. Results：80 traditional Chinese medicine patent compounds were finally collected，involving 244 traditional Chinese medicine，which were used 939 times in total. The properties of high-frequency traditional Chinese medicine were mainly warm and cold； the taste was mostly bitter and acrid； while the liver meridian and the heart meridian were the most common. The association rules with high support were “Schisandrae Chinensis Fructus-Ginseng Radix et Rhizoma”，“Schisandrae Chinensis Fructus-Ophiopogonis Radix”，“Glycyrrhizae Radix et Rhizoma-Chuanxiong Rhizoma”； the core traditional Chinese medicine mainly included Glycyrrhizae Radix et Rhizoma，Schisandrae Chinensis Fructus，Angelicae Sinensis Radix. Cluster analysis obtained 6 types traditional Chinese medicine with potential compatibility relationship； while factor analysis extracted 11 common factors. Conclusion：In the treatment of pulmonary heart disease，tonic and astringent medicine，blood stasis medicine，Phlegm-relieving cough and asthma medicine，such as Glycyrrhizae Radix et Rhizoma，Schisandrae Chinensis Fructus，Astragali Raadix，Angelicae Sinensis Radix，and Armeniacae Semen Amarum should be chose first； what’s more，the therapeutic principles that is to treat phlegm and blood stasis at the same time and co-regulation of qi and blood should be adhered，which can improve curative effect in clinical.