Roles of Histone Acetylation in Aging %0 Journal Article %D 2021 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2021.02.010 %P 53-64 %V 11 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_760.shtml} %8 2021-04-26 %X

As a complex multi-factor biological process，aging is characterized by the gradual decline of cell homeostasis，tissue function and body health over time. Aging weakens the gene expression control regulated by epigenetic factors. Histone modification is a key regulatory factor that controls chromatin structure and gene transcription，thereby affecting various important cellular biological processes. More and more studies have shown that histone acetylation under various environmental stimuli is involved in the regulation of translation，which affects gene expression and lifespan. In this review，we summarize the mechanisms of histone acetylation in gene regulation and senescence，describe the direct or indirect roles of histone acetylation in the aging-related gene expression and signaling pathways，and discuss the potential of histone acetylation as therapeutic targets against aging.