Epigallocatechin gallate (EGCG) , the main component of tea polyphenols, is a catechin monomer isolated from tea. It has a variety of biological activities such as antioxidation, anti-inflammation, anti-tumor, anti-metabolic diseases, cardiovascular and neuronal protective effects. In recent years, more and more studies related to the in vivo activity and medicinal values of EGCG have revealed that it may have important clinical application values. Therefore, this paper reviewed the advances in pharmacokinetics，pharmacology and toxicology of EGCG, so as to provide theoretical basis for the further development and utilization of EGCG.