Research Progress of SIRT1 in Cerebral Ischemia-Reperfusion Injury %0 Journal Article %D 2020 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2020.06.007 %P 41-44 %V 10 %N 6 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_740.shtml} %8 2020-12-26 %X

Acute ischemic stroke is a kind of disease with complicated pathogenesis and no effective treatment at present. Silencing information regulator 1(SIRT1)is a nicotinamide adenine dinucleotide(NAD+)-dependent deacetylase，and is one of the important regulators of aging，apoptosis and other physiological activities. Studies have shown that SIRT1 is closely related to the neuroprotective effect of cerebral ischemia-reperfusion injury and may be a new target for the treatment of acute ischemic stroke.