Carbapenem-resistant Klebsiella pneumoniae(Carbapenem-resistant Klebsiella pneumoniae，CRKP)is one of the important pathogenic bacteria isolated clinically and nosocomial infections. As the beta lactam class and aminoglycoside the wide use of broad-spectrum antibiotics，bacteria easy generation ultra broad spectrum beta lactamase，cephalosporins，enzyme and aminoglycoside modifying enzyme，to commonly used medicines including third-generation cephalosporin and aminoglycoside presents severe multiple drug resistance. Because CRKP is resistant to most antibiotics，it has become a very difficult problem in clinical treatment. It has become important to strengthen the monitoring of bacterial resistance and reduce bacterial resistance caused by overuse of antibiotics. Therefore，it is necessary to systematically sort out CRKP and discuss its drug resistance mechanism，so as to provide reference basis for rational selection of antibacterial drugs and optimization of medical resources in the future.