Alzheimer’s disease （AD） is characterized by progressive cognitive decline and memory loss，and its pathogenesis is complex. At present，no effective drugs and therapeutic approaches have been found clinically to fundamentally prevent and cure AD. Quercetin is a flavonoid phytoestrogen that simulates estrogen stimulation of estrogen receptors to produce weak estrogen activity and has a protective effect on the nervous system. Quercetin has high biological activity，wide source，no teratogenicity，no carcinogenesis，no lethal effect，so it has been widely concerned. In this review，the biological activity of quercetin，its neuroprotective effect on AD and its mechanism of action were reviewed，with a view to providing reference for the research of related drugs for AD.