|星空彩票电脑版
%A WANG Ling-yi, HUANG Bin, YU Li-mei, WU Qin, ZHANG Feng, SHI Jing-shan %T
Protective Effects of Dendrobium Polysaccharides on Learning and Memory
Deficits
in Aging Mice Induced by D-galactose%0 Journal Article %D 2012 %J ACTA NEUROPHARMACOLOGICA %R %P 1-6 %V 2 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_73.shtml} %8 2012-04-26 %X
Objective:To investigate the effects of Dendrobium polysaccharides on D-galactose-induced learning and memory deficits in aging mice.
Methods:Adult mice were given subcutaneous injection of D-galactose (120mg·kg
-1) daily for 60 d to produce aging-related syndrome, such as learning and memory deficits and alterations in tissue redox status. Dendrobium polysaccharides (80, 160 and 320 mg·kg
-1) were administrated by gavage daily for 60 d.
Results:Dendrobium polysaccharides significantly ameliorated D-galactose-induced cognitive deficits, as evidenced by the significant performance improvement in the Morris water maze, step-down and step-through tests. Dendrobium polysaccharides also prevented the elevation of malondialdehyde (MDA) in the brain and plasma and restored the antioxidant enzyme activities to normal levels, including superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and Na
+-K
+-ATPase.
Conclusions:Dendrobium polysaccharides is effective against D-galactose-induced aging and this effect appears to be due, at least in part, to its antioxidant activities.