Lasiosphaera seu Calvatia is a large medicinal fungus that is a dry fruiting body of the gray-shelled fungus，such as the peeled puffball，the big puffball or the purple puff. It is rich in nutrients and is described in the 2015 Pharmacopoeia. Indications for clearing the lungs and pharynx，stopping bleeding，for wind-heat depression，sore throat，cough，external treatment of nasal discharge，traumatic bleeding. This article reviews the types，chemical constituents and medicinal properties of puffballs for further reference.