Objective：To explore the mechanism of effective components of ginseng on osteoarthritis by using network pharmacology technology. Methods：TCMSP database was used to screen the main active compounds and pharmacodynamic genes of ginseng，and GeneCards and OMIM databases were used to screen the target genes related to osteoarthritis. Use R language to intersect target genes related to ginseng and osteoarthritis，and screen out gene targets for active compounds of ginseng to treat osteoarthritis. The gene network was drawn by Cytoscape software，and the ginseng-protein mutual aid map was constructed using the String database，and the core target genes were selected. Finally，R language was used to analyze the GO and KEGG pathways of the selected gene targets. Results：22 active compounds of ginseng were screened out，and a total of 51 target genes may be involved in the treatment of osteoarthritis. Obtained 144 GO biological processes and 143 KEGG signal pathways，which are mainly enriched in cell inflammation，bacterial infection，AGE-RAGE，TNF and other signal pathways. Conclusion：The action mechanism of ginseng in treating osteoarthritis may be related to antibacterial inflammation and reducing bacterial infection.