Alzheimer’s disease has caused a serious of public health problem，there are only two classes of drugs have been approved by FDA to treat the AD presently，but these medicines can only control the symptoms of AD，they can’t delay or block the progress of the disease process. This article first summarized the pathogenesis of AD，and then introduced two types of drugs used to treat AD which is approved by the FDA currently：cholinesterase inhibitors and NMDA receptor blockers. Finally，based on the possible mechanism of neural degenerative diseases we discussed the potential drugs for the treatment of AD，so as to provide evidences for the development of new AD drugs in the future.