|星空彩票电脑版
%A GUO Yan-yan, QI Feng-yan, ZHAO Ming-gao %T
Involvement of Large-conductance Ca2+-activated K+Channels in the Synaptic Transmission in the Lateral Amygdala%0 Journal Article %D 2012 %J ACTA NEUROPHARMACOLOGICA %R %P 10-19 %V 2 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_68.shtml} %8 2012-02-26 %X
Objective:Large-conductance Ca
2+-activated K
+(BK
Ca) channels are highly expressed in the lateral amygdala (LA), which is involved in stress disorders, but the role of these BK
Cain the neuronal circuits are poorly understood. In the previous study, we found a significant reduction in BK
Cachannel expression in the amygdala of mice undergoing acute stress, which was accompanied by anxiety-like behaviors. In this study, we focused on the role of BK
Cachannels in the synaptic transmission and plasticity in the lateral amygdala.
Methods: Behavioral tests, western-blot analysis and electrophysiological recordings were performed.
Results: First, we found the co-distribution of BK
Cachannels immunoreactively with glutamatergic neuronal marker CaMKIIα or interneuron marker GAD-65 in the LA. In addition, both NR2A and NR2B were co-localized with the BK
Cachannels and formed a heteroreceptor complex in the soma and dendrites of the amygdala neurons. Furthermore, block of the BK
Cachannels notably facilitated long-term potentiation (LTP) induction at the thalamo-LA synapse.
Conclusion: BK
Cachannels play critical roles in the synaptic plasticity in the LA.