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%A ZHAI Yun-peng, ZHU Xia, LU Qian, WANG Jian-yun, YIN Xiao-xing, LIU Yao-wu %T
Total Saponins fromRhizoma AnemarrhenaeIncrease Acetylcholinesterase Activity in the Hippocampus of Diabetic Rats%0 Journal Article %D 2012 %J ACTA NEUROPHARMACOLOGICA %R %P 1-9 %V 2 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_67.shtml} %8 2012-02-26 %X
Objective:To investigate the effects of total saponins from
Rhizoma Anemarrhenae(TS) on acetylcholinesterase (AchE) activity in the hippocampus of streptozotocin-induced diabetic rats and their possible mechanisms.
Methods:Diabetic rats were treated with TS (200 mg?kg
-1, ig.) for 8 weeks, and their blood glucose and body weight were measured monthly and weekly, respectively. The hippocampus was obtained for assays of AchE activity as well as levels of malondialdehyde (MDA) and reduced glutathione (GSH); blood was collected for assays of levels of MDA, GSH and glucose.
Results:Compared with that of the age-matched normal rats, AchE activity was markedly increased in the hippocampus of diabetic rats, and TS treatment blocked such an increase. Meanwhile, diabetes significantly elevated the MDA level and reduced GSH level both in the hippocampus and the serum, and TS treatment significantly prevented such changes. In addition, TS significantly decreased the fasting blood glucose level and increased the body weights of diabetic rats.
Conclusion:TShas an inhibitory effect on AchE activity in the hippocampus in diabetic rats, which is at least partly due to its antioxidant and anti-diabetic activity.