Silicosis is an occupational disease mainly caused by pulmonary fibrosis caused by long-term inhalation of high concentrations of dust during the production process. It is the most common occupational disease. The pathogenesis of silicosis has been studied at home and abroad for a long time. It is essential to explore the pathogenesis of silicosis，study treatment methods，and establish animal models. This article provides a more comprehensive selection of clinical research applications for silicosis through a relatively comprehensive introduction to silicosis animal models.