Glioma is the primary brain tumor generated by cancerous brain and spinal cord glial cells. It’s the most common malignant tumor，comes from neuroepithelial cells and is mainly caused by EGF receptor mutation. Glioma cells also secrete VEGF factors，which can lead to more serious consequences. Currently，the treatments for the disease include surgery， radiotherapy，chemotherapy and other means，however，it can only relieve the symptoms，be completely cured hardly and often relapse. In recent years，the researches of drug therapy have not been stopped. Morus alba L is the root bark of Morus alba L， which is mainly used for treating lung heat，wheezing and phlegm，stopping lung by drinking water，and wheezing and acute wheezing after swelling. The Mulberin extracted from Morus alba L is the mainly active ingredient. Studies have shown that Mulberin has a certain effect on EGF in cancer cells，which in turn affects the expression of EGF receptor. Mulberin also has a certain effect on VEGF，so it can be used to treat Glioma by affecting EGF and VEGF. This article reviewed the development status of Glioma，the research of Mulberin and its effect on EGF and VEGF. In the meantime，a new idea of treating Glioma with Mulberin is proposed based on above of conclusions.