Toxoplasma gondii is an obligate intracellular parasitic protozoa that invades almost all nucleated cells. The worm enters the body and spreads to the tissues and organs along with blood circulation，causing toxoplasmosis. Toxoplasma gondii has a tropism on nerve tissue，causing abnormalities in the central nervous system，often manifested as encephalitis， meningoencephalitis，epilepsy and mental disorders. The damage of Toxoplasma gondii to nerve tissue has been widely concerned. The blood-brain barrier is a place where the brain tissue communicates with the outside world. Its unique structure delays or blocks the process of Toxoplasma gondii invasion into the brain to a certain extent，but Toxoplasma gondii still invades the central nervous system through the blood-brain barrier，causing the tissue cell damage in host brain. This paper describes the damage of Toxoplasma gondii to the central nervous system and the mechanism through the blood-brain barrier.