Pulmonary edema is a relatively rare disease. Mostly，for a certain reason，a large amount of tissue fluid cannot be absorbed by the pulmonary lymph and venous system in a short time，and pulmonary edema occurs. Pulmonary edema refers to the pathological state in which the fluid in the pulmonary capillaries infiltrates into the interstitial lung and alveoli，and the amount of extrapulmonary fluid increases. It is one of the clinical emergencies，and there are many hypotheses about its mechanism，and each has experimental basis，but both the process of the occurrence and development of pulmonary edema cannot be fully explained. Therefore，some animal models are often used to study the pathogenesis of the disease and related experimental research. This article is of great significance to the application of basic and clinical research through the detailed description and evaluation of the method of inducing pulmonary edema in animals.