Adrenomedullin （ADM） is a vasodilator active polypeptide consisting of 2 amino acids. Its main characteristic is that the 16th and 21st cysteine residues are linked y disulfide bonds. It is highly expressed in heart，lung and other important organs. The main arts of synthesis and secretion are vascular endothelial cells and smooth muscle cells，in which ndothelial cells play a dominant role. It has many functions，such as vasodilation，hypotension， iuresis，anti-inflammation，participation in oxidative stress，inhibition of smooth muscle cell roliferation，migration and differentiation，etc. It has many studies in cardiopulmonary-related iseases. This article reviews the research progress of ADM in cardiopulmonary-related diseases， n order to provide new ideas for clinical treatment.