|星空彩票电脑版
%A ZHEN Xue-chu %T
Targeted to Serotonergic and Adenosine Systems in Parkinsons Disease Drug Development%0 Journal Article %D 2018 %J ACTA NEUROPHARMACOLOGICA %R %P 72-73 %V 8 %N 5 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_579.shtml} %8 2018-10-26 %X Parkinson's disease (PD) is a progressive neurodegenerative disorder. While dopaminergic agents are effective in reliving the motor symptoms, however, chronic dopamine replacement treatment could also induce motor fluctuation and dyskinesia. In addition, there is still a clinical unmet need for novel medications that can treat the non-motor symptoms. Recent evidence suggests that the serotonergic nervous system may be an important target for both motor and non-motor symptoms for PD Meanwhile, adenosine A2A receptors enriched in basal ganglia areas and their antagonistic role towards dopamine receptor stimulation, have positioned A2A receptor antagonists as an a promising target to improve the motor deficits. We have developed a series of dual dopamine receptor and 5-HT1A receptor ligands and A2A receptor antagonists either through natural resource or rational design. We pharmacologically characterized those compounds and provided clear evidences that dual 5-HT/dopamine or A2A receptor antagonist exhibited excellent anti-Parkinsonian effect while it reduced the development of dyskinesia and effectively relieved some of the non-motor symptoms in PD animal models.