|星空彩票电脑版 %A WANG Shu, ZHANG Li, XUE Gui-ping %T Protective Effects of Emodin on the Memory of Mice Experiencing Cerebral Ischemia Reperfusion%0 Journal Article %D 2011 %J ACTA NEUROPHARMACOLOGICA %R %P 1-6 %V 1 %N 6 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_53.shtml} %8 2011-12-26 %X Objective:To study the protective effects of emodin on the memory of mice experiencing cerebral ischemia reperfusion and their underlying mechanisms. Methods:Using improved Himori method, cerebral ischemia reperfusion injury was produced in conscious mice by temporarily obstructing bilateral common carotid arteries. The protective effects of emodin (10.0, 1.0, 0.1 mg.kg ^-1，ip) on the memory of these mice were examined using the step-through test, shuttle box test, antihypoxia test under normal pressure, test of acute cerebral hypoxia induced by decapitated mice and test of NaNO ₂histotoxic anoxia,. Meanwhile, the superoxide dismutase (SOD) activity and glutathione peroxidase (GSH-PX) activity were also measured. Results:Emodin could attenuate the memory impairment induced by cerebral ischemia reperfusion injury, prolong the antihypoxic survival time, and increase the activities of GSH-PX and SOD. Conclusions:Emodin showed protective effects on the memory of mice with cerebral ischemia reperfusion injury. The possible mechanism may involve the enhancement of the activities of GSH-PX and SOD, which leads to the increased oxygen free radicals scavenging ability, enforced antihypoxic capacity and alleviation of cerebral ischemia damage.

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