|星空彩票电脑版
%A ZAN Gui-ying，SUN Xiang，LI Qing-lin，LIU Jing-gen %T
Research Progress of the Role and Underlying Mechanism of Dynorphin/κ Opioid Receptor in the Development of Depression%0 Journal Article %D 2018 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2018.01.007 %P 54-64 %V 8 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_516.shtml} %8 2018-02-26 %X Depression is a serious mental disorder charactered by high prevalence，major depression always result in great harm to society. At present，the most popular antidepressants including monoamine reuptake inhibitors have some deficits including slower effect，side-effect. At the same time，some patients do not response adequately to the antidepressant medication. The development of drugs targeting opioid receptor has shown promising prospect，clinical studies have demonstrated that κ opioid receptor antagonist Buprenorphine could possibly cure depressive symptoms in patients with classical antidepressants treatment-resistant depression. In present review，we discuss the recent progress of the role of κ opioid receptor in different brain regions during the development of depression，and introduce the association between dynorphin/κ opioid receptor and CRF as well as monoamine system. Furthermore，we briefly introduce the upstream and downstream molecules of κ opioid receptor that contribute to the development of depression.