|星空彩票电脑版
%A WANG Yun，ZHEN Xue-chu %T
An Update on Allosteric Modulator of Sigma-1 Receptors: Potential Applications%0 Journal Article %D 2018 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2018.01.005 %P 35-44 %V 8 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_514.shtml} %8 2018-02-26 %X Sigma-1 receptors are involved in the pathophysiological process of several neuropsychiatric diseases. Allosteric modulation of receptor represents an important mechanism for receptor functional regulation. Compared to orthodox ligands of sigma-1 receptor，allosteric modulator has tremendous advantages in selectivity and safety. Thus，development of allosteric modulation toward sigma-1 receptors has become a new approach for treatment of neuropsychiatric diseases. Here，we summarized the progress of biological functions and developed ligands of sigma-1 receptors，and discussed the potential applications of novel allosteric modulator in some neuropsychiatric diseases.