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%A LI Dong-wei, DOU De-qiang %T Protective Effect of PPT and Ginsenoside-Re in MPP
+-treated SH-SY5Y Cells %0 Journal Article %D 2011 %J ACTA NEUROPHARMACOLOGICA %R %P 1-7 %V 1 %N 5 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_44.shtml} %8 2011-10-26 %X
Objective:To investigate the protective effect of PPT (protopanaxatriol group) and ginsenoside-Re on 1-methyl-4-phenylpyridinium ion (MPP+)-induced damage in SH-SY5Y（human dopaminergic neuroblastoma cell line）cells.
Methods:SH-SY5Y cells were treated with different concentrations of PPT, ginsenoside-Re or MPP+ containing serum. MTT colorimetry was used to test the viability of the cells and the survival rates were calculated and analyzed.
Results:Cells treated by either 5 µmol•L-1, 10 µmol•L-1 PPT or ginsenoside-Reshowed significantly higher viability as compared to control group (P<0.05). In addition, 10% PPT treated or ginsenoside-Remedicated serum treated groups showed similar protective effect.
Conclusion:PPT and ginsenoside-Re have neuroprotective effects in a cell model of Parkinson’s disease MPP
+-induced SH-SY5Y cell death, suggesting that both PPT and ginsenoside-Re may have anti-PD effect.