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%A YUAN Heng-jie，LOU Jian-shi %T Research Progress in the Mechanisms of Cerebral Ischemia Hypoxia Preconditioning Antagonizing Cerebral Ischemia and Hypoxia Injury %0 Journal Article %D 2011 %J ACTA NEUROPHARMACOLOGICA %R %P 42-47 %V 1 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_41.shtml} %8 2011-08-26 %X The phenomenona of ischemia/hypoxia preconditioning were first discovered in heart. Numerous studies，carried out at different levels，have confirmed that there are also preconditioning phenomenona in brain，and the phenomenona of ischemia/hypoxia preconditioning in brain have become a hot topic in the field of ischemia and hypoxia. Cerebral ischemia/hypoxia preconditioning (CIP) can decrease cell apoptosis，increase the anti-oxidant ability and decrease oxidant injury，increase the generation of hypoxic inducible factor-1 and heat shock protein 70 through multiple signal transduction pathways. There are interactions among the mechanisms about CIP which are relatively independent.