|星空彩票电脑版
%A ZHANG Li-hang， YIN Ming %T
Thinking of Influences of Small Molecules on Neural Stem Cell Neurogenesis%0 Journal Article %D 2017 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2017.01.001 %P 1-9 %V 7 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_342.shtml} %8 2017-02-26 %X Recently， there is considerable interest in the development of stem cellbased strategies for the treatment of Alzheimer’s disease， one of the neurodegenerative diseases. To date， so-called regenerative approaches have focused mainly on the development of cell transplantation therapies using cells derived from pluripotent embryonic stem cells （ESCs）. Although some exciting preliminary reports have been described in regard of the efficacy of
ESC-derived replacement therapies， explorations involving ex vivo manipulated ESCs are hindered by events of mutation， immune rejection， and ethical controversy. An alternative approach involves direct in vivo modulation of endogenous adult stem cell populations using small molecules. Although many results have been reported， the interaction between neural stem cell and local niche and the specific signal mechanisms of neural stem cell remain to be
elucidated. Here we present the thinking of the chemical approaches to the regulation of neural stem cell biology that are yielding new biological insights and that may potentially lead to innovative new drugs.