|星空彩票电脑版
%A ZHANG Hai-wei，ZHANG Li %T
Review of P-Glycoprotein on the Blood-Cerebrospinal Fluid Barrier%0 Journal Article %D 2016 %J ACTA NEUROPHARMACOLOGICA %R 10.3969/j.issn.2095-1396.2016.02.009 %P 53-64 %V 6 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_304.shtml} %8 2016-04-26 %X Blood-cerebrospinal fluid barrier（blood-CSF barrier） is a dynamic physiological structure，which is composed of brain microvascular endothelial cells，astrocytes and pericytes，playing an important role in maintaining homeostasis in the central nervous system（CNS）. P-glycoprotein（P-gp） is a common membrane protein in the blood cerebrospinal fluid barrier，which is expressed in the brain microvascular endothelial cells，and it limits the toxic substances and a large number of drugs for the treatment of the central nervous system into the brain. Therefore the efflux transport mechanism of P-gp in the blood-CSF barrier is a break though point for the treatment of nervous system disease. This article mainly reviews research progress on the basic structure and trans-port mechanism of P-gp，it’s regulation mechanism in the physiological and pathological conditions and inhibitors，to provide references for drug development and blood-CSF barrier transport mechanism of CNS.