%A Ren Xu-ying，Mou Qun-fang，Luo Yi-ren，Wang Jue，Wang Yue，Zhang Fang
%T <strong>Antiemetic Effect and Mechanism of Small Pinelliae Decoction on Mink Vomit Model</strong>
%0 Journal Article
%D 2011
%J ACTA NEUROPHARMACOLOGICA
%R 
%P 23-26
%V 1
%N 3
%U {http://actanp.hebeinu.edu.cn/CN/abstract/article_29.shtml}
%8 2011-06-26
%X <strong>Objective</strong>：&nbsp;To study the antiemetic effect of Small Pinelliae Decoction (SPD) and its mechanism. <strong>Methods</strong>： he active ingredients were extracted from TSPD(pinellia tuber:ginger=1:1) to make the granules. Cisplatin(7.5 mg&middot;kg<sup>-1</sup>, ip) and apomorphine(1.6 mg&middot;kg<sup>-1</sup>, ip) were used to prepare mink vomiting model. After 30 min of SPD (equivalent to 4.0, 1.0 g&middot;kg<sup>-1</sup> crude drug) ig. adminstration, minks were administered of cisplatin or morphine to study the inhibitory effect and mechanism of SPD on the two models of vomiting. <strong>Results</strong>： SPD could inhibit acute and delayed vomiting induced by cisplatin (within 72 h) in the minks, reduce the number of retching and vomiting(<em>P</em>&lt;0.01), prolong the latency to vomit (<em>P</em>&lt;0.01), and inhibit the expression of NK<sub>1</sub> receptor&nbsp;in central (the area postrema) and peripheral (ileum tissue) tissues (<em>P</em>&lt;0.05). SPD could also inhibit vomiting induced by apomorphine (within 6 h) (<em>P</em>&lt;0.01), reduce significantly the ratio of vomiting (<em>P</em>&lt;0.05) and did not affect the latency to vomit. <strong>Conclusion</strong>： SPD can inhibit vomiting induced by cisplatin and apomorphine, and its mechanism is related to the inhibition of central and peripheral NK<sub>1</sub> receptor expression.