|星空彩票电脑版
%A ZHANG Cheng-long, ZHANG Zhi-feng, MENG Xian-yong, DONG Xiao-hua %T
Preparation and Quality Evaluation of Osthole Liposome%0 Journal Article %D 2015 %J ACTA NEUROPHARMACOLOGICA %R %P 26-32 %V 5 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_271.shtml} %8 2015-08-26 %X
Objective：To research the best preparation technology and prescription, and to evaluate its quality.
Methods：Osthole liposome was prepared through film-ultrasonic dispersion method. Encapsulation efficiency was taken as index, the preparation technology and prescription were optimized through single factor and orthogonal test, and particle size and Zeta potential were measured.
Results: The optimal formulations were cholesterol/lecithin=1:3, drug/lecithin =3:20, pH=7.9, and at 45℃ reactive temperature. The entrapment efficiency was over 80%. Average particle size was（466.6 ± 6.4）nm and Zeta potential was（-29.0 ± 1.8）mV.
Conclusion：The preparation prescription and technology were feasible and stable, and osthole liposome has high entrapment efficiency and good stability.