|星空彩票电脑版
%A LI Dong-fang, ZHAO Hai-bin, JIANG Tian-yuan, ZHAI Yao-yao, YANG Dan-dan %T
The Skills of Intracerebral Hemorrhage Rat Model by Type VII Collagenase Injection%0 Journal Article %D 2015 %J ACTA NEUROPHARMACOLOGICA %R %P 22-25 %V 5 %N 4 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_270.shtml} %8 2015-08-26 %X
Objective: To study the skills of intracerebral hemorrhage model by injecting type Ⅶ collagenase into brain region in rats.
Methods: The animal model of intracerebral hemorrhage was induced by the injection of type Ⅶ collagenase into caudate nucleus of rats with stereotactic instrument and improved methods. And then evaluate the feasibility and stability of the model through behavioral assessment initially.
Results: we had made 150 rat models, two rats died, nine rats was not successful. The success rate of intracerebral hemorrhage model was 92.7%.
Conclusion: The method of injecting type Ⅶ collagenase can be used to build the animal model of intracerebral hemorrhage ideally and steadily. Because of the simple experiment operation, it has a great promotional vaule.