|星空彩票电脑版
%A ZHOU Si-bai, LI Jin-ze, LIU Rui, ZHANG Tian-tai %T
Recent Development of the Flavonoids on the Treatment of Alzheimer’s Disease%0 Journal Article %D 2015 %J ACTA NEUROPHARMACOLOGICA %R %P 51-58 %V 5 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_256.shtml} %8 2015-02-26 %X Flavonoids, a class of secondary metabolites present in plants, are the active ingredients of a variety of herbals. An increasing body of evidences demonstrate that the flavonoids could significantly improve the cognitive function of Alzheimer’s diseases (AD) in animal models and alleviate the progression of AD, exerting positive therapeutic effect. The mechanism is complex, including suppressing inflammatory modulators production, inhibiting Aβ aggregation and tau protein phosphorylation, and reducing the generation of free radical generation through multiple intracellular signaling pathways. Summarizing the relationship between the structure and their biological actions of the flavonoids and the possible mechanisms in the treatment of AD, the aim of this review, is to obtain a further understanding of how flavonoids participate in relieving the progression of AD and providing some inspiration for the flavonoids applying in AD treatment.