|星空彩票电脑版
%A CHEN Qian, FENG Fei, CHEN Wen-ming, YANG Xiao-yan, LUO Yong %T
Inf luence of Saff lower Injection on Expression of Bax and Bcl-XL/Bcl-2 Protein in the Cortex of Rat after Ischemia-Reperfusion Injury%0 Journal Article %D 2015 %J ACTA NEUROPHARMACOLOGICA %R %P 15-18 %V 5 %N 1 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_252.shtml} %8 2015-02-26 %X
Objective：To explore the influence of safflower injection on expression of Bax， Bcl-2 and Bcl-XL protein in the cortex of rat after ischemia-reperfusion injury.
Methods：30 healthy male SD rats were randomly divided into six groups，as indicated，control group，model control group，safflower injection low dose group（ 0.8 mL·kg-1），middle dose group（ 1.6 mL·kg-1），high dose group（ 3.2 mL·kg-1） and Nimodipine group（ 2.0 mL·kg-1）. The focal cerebral ischemia-reperfusion injury model was established by thread technique，and the expression of Bax，Bcl-2 and Bcl-XL protein in the rat brain cortex was detected through immunohistochemical methods.
Results：We found that the expression of positive cells of Bax，Bcl-2 and Bcl-XL protein was signifi cantly increased in the surrounding area of the ischemic brain tissue in the model group，compared with the control group（ P<0.05）； and the expression of positive cells of Bax protein was reduced and the expression of Bcl-2，Bcl-XL protein was rised in the surrounding area of the ischemic brain tissue in the safflower injection low dose group，middle dose group，high dose group and Nimodipine group，compared with the model group（ P<0.05）.
Conclusion：Safflower injection can protect cerebral neurons from apoptosis through augmenting the expresson of Bcl-2，Bcl-XL and decreasing the expression of Bax protein after ischemia-reperfusion injury.