|星空彩票电脑版
%A WANG Ting-ting, ZHANG Yu-yao, WANG Ji-xi, LIU Yang, CHEN Yong-chun, JIANG Guo-hua %T
Effect of Resveratrol on Longevity ofCaenorhabditis Elegansand Its Potential Mechanism%0 Journal Article %D 2015 %J ACTA NEUROPHARMACOLOGICA %R %P 1-6 %V 5 %N 5 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_246.shtml} %8 2015-10-26 %X
Objective：To investigate the effect of resveratrol on longevity of Caenorhabditis elegans （C.elegans） and its potential mechanism.
Methods：Three types of C.elegans，wild type （N2），daf-2 mutant（ e1370） and daf-16 mutant（ mu86） were cultured with different concentrations of resveratrol （0、25、50、100 μmol·L
-1）. The survival rates were measured and the effect of resveratrol on life span was recorded.
Results：Compared with the DMSO group，significantly extension of the normal life span of three types of C.elegans（ N2，daf-2 and daf-16 mutants） was observed containing 25、50、100 μmol·L
-1resveratrol.
Conclusion：Resveratrol can extend the life span of C.elegans，possible not associated with DAF-2/insulin-like signaling pathway.