|星空彩票电脑版
%A WANG Xiao-qin, ZOU Yu-an, GUO Chun-yan %T
Research Progress of the Mechanism of Cerebral Ischemic Preconditionining and Cerebral Ischemic Tolerance%0 Journal Article %D 2015 %J ACTA NEUROPHARMACOLOGICA %R %P 30-37 %V 5 %N 2 %U {http://actanp.hebeinu.edu.cn/CN/abstract/article_241.shtml} %8 2015-04-26 %X Cerebral ischemic preconditioning (CIP) demonstrates an endogenous protective mechanism against ischemic injury with a brief sublethal ischemia increases the tolerance of the brain tissue to subsequent ischemia. Cerebral ischemic tolerance refers to a phenomenon of central nervous system adaptation to any subsequent ischemia by CIP. Establishing such a tolerance involved multiple mechanisms: the NO and NO related signaling pathways, excitatory and inhibitory neurotransmitter, inflammation factors, adenosine, cell energy metabolism and mitochondrial, autophagy-lysosome activation, inhibition of cell death and activate DNA repair and self-repair/remodeling mechanism, vascular remodeling and protect the blood brain barrier, etc. A better understanding of the endogenous neuroprotective mechanisms by which CIP and IP protects against cerebral ischemic insults could help us develop new therapeutic and preventive strategies for ischemia anoxic encephalopathy.